This figure shows how the STAIG framework can successfully identify spatial domains by integrating image processing and contrastive learning to analyze spatial transcriptomics data effectively.

Breakthrough research details how distinct tissue niches and cell communication contribute to chronic active lesions in MS. Study: Cell type mapping reveals tissue niches and interactions in ...

Biological systems are inherently three-dimensional—tissues form intricate layers, networks, and architectures where cells interact in ways that extend far beyond a flat plane. To capture the true ...

A new software tool, ovrlpy, improves quality control in spatial transcriptomics, a key technology in biomedical research. Developed by the Berlin Institute of Health at Charité (BIH) in international ...

Scientists at Duke-NUS Medical School have developed two powerful computational tools that could transform how researchers study the "conversations" between cells inside the body. The tools, called ...

A novel spatial transcriptomics atlas developed by Northwestern Medicine scientists may improve the understanding of niche cellular interactions in the gastrointestinal tract that promote the ...

Spatial biology is a rapidly advancing discipline that examines biological molecules (such as DNA, RNA, and proteins) within their native locations in tissues. This approach offers critical insight ...

The liver is remarkable for its ability to regenerate after injury, yet when this process fails, acute liver failure (ALF) carries devastating outcomes. Traditional research methods, reliant on bulk ...

Knowing the location of a gene within intact tissue or a single cell allows scientists to unlock unknown cellular functions. This information is often lost in most genetic sequencing techniques, but ...

Biological tissues are made up of different cell types arranged in specific patterns, which are essential to their proper functioning. Understanding these spatial arrangements is important when ...